From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
SynergyEmerging evidence
What is happening. Prebiotic fermentation may support mineral solubility and absorption, though GOS should not replace adequate calcium intake.
Mechanism. SCFA production and lower colonic pH can increase mineral solubility.
Recommendation. Use as adjunctive diet support, not as osteoporosis treatment.
Stack Score
How it moves the number.
Effect on the composite score
If both Calcium and Galactooligosaccharides (GOS) are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Micka A et al. GOS constipation RCT. Nutrients. 2022.Needs sourceNo link