NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Calcium and Silicon: what the published research says

PubMed indexes 8 records that name Calcium and Silicon together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Calcium and Silicon. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Calcium and Silicon.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial.

BMC musculoskeletal disorders · 2008 · PMID 18547426

Randomized Controlled Trial

“Combined therapy of ch-OSA and Ca/Vit D3 had a potential beneficial effect on bone collagen compared to Ca/Vit D3 alone which suggests that this treatment is of potential use in osteoporosis. NTR 1029.”

Spector et al. · Authors' conclusion

Names both Calcium and Silicon in its title.

Silicon-calcium fertilizer increased rice yield and quality by improving soil health.

Scientific reports · 2024 · PMID 38849431

“In terms of benefit analysis combined with cost, the SC treatment had the highest benefit effect. Taken together, in mildly cadmium-polluted paddy fields, the application of silicon-calcium fertilizer improved the soil quality, thereby increased the yield and quality of rice, and had the best effect on increasing income.”

Yuan et al. · From the abstract

Names both Calcium and Silicon in its title.

Production and Characterization of Calcium Silica Aerogel Powder as a Food Additive.

ACS omega · 2023 · PMID 37008093

“The results showed that adding CSA7 powder to the rock salt powder at a rate of 1% (w/w) improved the flow behavior from the cohesive region to the easy-flow region. Consequently, calcium silica aerogel powder with a high surface area and high WVAC might be considered as an anticaking agent to use in powdered foods.”

Karakuzu Ikizler et al. · From the abstract

Names both Calcium and Silicon in its title.

Confinement induces stable calcium carbonate formation in silica nanopores.

Nanoscale · 2022 · PMID 35796623

“The presence of fewer water molecules in the first hydration shell of calcium ions in confinement compared to in bulk fluids contributes to stable calcium carbonate formation. These studies show that nanoporous siliceous environments favor the formation of stable calcium carbonate formation.”

Asgar et al. · From the abstract

Names both Calcium and Silicon in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Calcium, Silicon, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.