NutriStack
Calcium and Silicon, a synergy.
Silicon (as orthosilicic acid) added to calcium and vitamin D stimulates markers of bone collagen formation and may improve bone mineral density beyond calcium and vitamin D alone.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Silicon (as orthosilicic acid) added to calcium and vitamin D stimulates markers of bone collagen formation and may improve bone mineral density beyond calcium and vitamin D alone.
Mechanism. Silicon stimulates osteoblast differentiation and type I collagen synthesis, providing the organic matrix into which calcium mineralizes, complementing calcium's role as the mineral substrate.
Recommendation. Reasonable to include silicon alongside calcium for bone support. Use orthosilicic acid or a well-absorbed silicon form at typical doses (around 6 to 10 mg elemental silicon daily).
Sources (2)
- Spector TD et al., Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium and vitamin D3 stimulates markers of bone formation in osteopenic females, BMC Musculoskeletal Disorders, 2008
- Jugdaohsingh R, Silicon and bone health, Journal of Nutrition Health and Aging, 2007
Stack Score
How this pair moves the number.
Effect on the composite score
If both Calcium and Silicon are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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