NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Calcium and Strontium: what the published research says

PubMed indexes 8 records that name Calcium and Strontium together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Calcium and Strontium. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Calcium and Strontium.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Strontium-Substituted Calcium Orthophosphates: Structure, Stability, Morphology, and Biomedical Applications.

International journal of molecular sciences · 2025 · PMID 40565355

ReviewHuman subjects

“This paper provides an overview of the present knowledge on the substitution of calcium with strontium in calcium orthophosphates. In particular, attention is focused on the influence of the substitution on the structure, morphology, and stability of calcium orthophosphates, as well as on the impact of strontium-substituted calcium phosphates on biomaterials in bone substitution/repair.”

Bigi et al. · From the abstract

Names both Calcium and Strontium in its title.

Titanium- and Strontium-Infused Calcium Silicates Toward Restorative and Regenerative Purposes.

Cureus · 2024 · PMID 38910673

“This study successfully fabricated an improved calcium silicate-based material with enhanced regenerative properties and excellent biocompatibility. This newly formed substrate holds promise for providing superior restorative solutions and aiding in conservative treatment modalities during dental procedures.”

Patel et al. · Authors' conclusion

Names both Calcium and Strontium in its title.

Identification of strontium substitution mechanism in hematite via calcium solution.

Chemosphere · 2023 · PMID 37619756

Human subjects

“This substitution could be attributed to the physicochemical similarities between calcium and strontium. This study confirms the substitution of Sr with Ca, highlighting the physicochemical similarity of the Sr and Ca that facilitates substitution reactions.”

Song et al. · From the abstract

Names both Calcium and Strontium in its title.

Strontium increasing calcium accessibility from calcium citrate.

Food chemistry · 2022 · PMID 34343801

“Strontium binding to citrate was found endothermic, ΔH0 = 45 kJ∙mol-1 at 25 °C, while calcium binding shows variation from ΔH0 = 94 kJ∙mol-1 at 10 °C becoming exothermic above physiological temperature with ΔH0 = -9 kJ∙mol-1 at 45 °C as determined from temperature and concentration variation in electric conductivity.”

Liu et al. · From the abstract

Names both Calcium and Strontium in its title.

Can strontium replace calcium in bioactive materials for dental applications?

Journal of biomedical materials research. Part A · 2022 · PMID 35770805

“The tricalcium silicate caused elemental migration of calcium and silicon in the local tissues shown by the elemental mapping but no deposition of calcium was identified in the peripheral organs verified by the assessment of the digested tissues. Strontium can substitute calcium in bioactive materials without adverse local or systemic effects.”

Pelepenko et al. · From the abstract

Names both Calcium and Strontium in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Calcium, Strontium, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.