What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Fish Oil + Rutin pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·a caution·Emerging evidence

Fish Oil + Rutin

Q: Can I take Fish Oil and Rutin together?

Possibly, but with caution. Fish Oil and Rutin have a documented caution-tier interaction. Both rutin (and its quercetin metabolite) and the omega-3 fatty acids in fish oil can modestly reduce platelet aggregation. Used together, and especially alongside antiplatelet or anticoagulant medication, the additive effect could theoretically increase bleeding tendency.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Caution Emerging evidence

Both rutin (and its quercetin metabolite) and the omega-3 fatty acids in fish oil can modestly reduce platelet aggregation. Used together, and especially alongside antiplatelet or anticoagulant medication, the additive effect could theoretically increase bleeding tendency.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Fish Oil and Rutin

Pair type

Caution

Evidence

Emerging

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

CautionEmerging evidence

What is happening. Both rutin (and its quercetin metabolite) and the omega-3 fatty acids in fish oil can modestly reduce platelet aggregation. Used together, and especially alongside antiplatelet or anticoagulant medication, the additive effect could theoretically increase bleeding tendency.

Mechanism. Flavonoids can inhibit platelet aggregation and thromboxane formation, while EPA/DHA shift eicosanoid balance toward less aggregatory species; effects on hemostasis may be additive.

Recommendation. Generally safe for most people, but use caution if you take anticoagulants/antiplatelets, have a bleeding disorder, or are approaching surgery; discontinue before procedures and discuss with a clinician.

Stack Score

How it moves the number.

Effect on the composite score

If both Fish Oil and Rutin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Ganeshpurkar A, Saluja AK. The pharmacological potential of rutin. Saudi Pharmaceutical Journal. 2017.Needs sourceNo link

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