Supplement × Prescription·Evidence index
PubMed indexes 8 records that name Alcohol and Hydroxyzine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.
Every statement below is attributed to a named, dated, linked source.
This page lists published research relevant to Alcohol and Hydroxyzine. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
“Concomitant administration of bilastine (at therapeutic dose) and alcohol does not produce greater central nervous system depressant effects than ACL alone.”
Names both Alcohol and Hydroxyzine in its title.
“Present results showed that single oral doses of rupatadine 10 mg in combination with alcohol do not produce more cognitive and psychomotor impairment than alcohol alone. Higher doses of rupatadine, in combination with alcohol, may induce cognitive and psychomotor deterioration as hydroxyzine and cetirizine at therapeutic doses.”
Names both Alcohol and Hydroxyzine in its title.
“Fexofenadine 180 mg did not have disruptive effects on objective measures related to driving a car and aspects of psychomotor and cognitive function, even when combined with a dose of alcohol equivalent to 0.3 g/kg body weight, in a study in which the psychometric assessments were shown to be sensitive to impairment.”
Names both Alcohol and Hydroxyzine in its title.
Names both Alcohol and Hydroxyzine in its title.
Names both Alcohol and Hydroxyzine in its title.
“SIGNIFICANCE STATEMENT: Through the identification of alcohol dehydrogenase (ADH) isoforms catalyzing hydroxyzine aldehyde formation by recombinant human ADH, the study revealed that several common organic solvents strongly inhibit ADH1. This highlights the need to consider the unintended inhibitory effects of such solvents on ADH activity when solubilizing lipophilic compounds.”
Names both Alcohol and Hydroxyzine in its title.
“The quantitation limit, linearity and recoveries were found to be 0.56 ppm, 0.56-7.49 ppm (r2 > 0.9985) and 93.6-99.3%, respectively. The proposed method was highly compatible and was used effectively to estimate CEE traces in different stages of drug synthesis and in tablet dosage forms of hydroxyzine for routine and stability testing.”
Names both Alcohol and Hydroxyzine in its title.
“It was considered that the main mechanism of a rise of BHC was not metabolic interaction between hydroxyzine and ethanol, but an enhancement of intestinal absorption of hydroxyzine due to ethanol. It was also found that hydroxyzine in blood distributed rapidly into bodily tissues.”
Names both Alcohol and Hydroxyzine in its title.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Alcohol, Hydroxyzine, and several hundred other substances.
The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
