NutriStack
Alcohol and Lorazepam, contraindicated.
Alcohol compounds lorazepam's sedating, amnestic, and coordination-impairing effects. Even if lorazepam is not strongly CYP-metabolized, the interaction is pharmacodynamic and can still cause dangerous impairment. Combining them raises the risk of falls, blackouts, aspiration, and respiratory depression.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Contraindicated
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- −25 to your Stack Score (per scored contraindication row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Contraindicated · Strong evidence
Contraindicated
What is happening. Alcohol compounds lorazepam's sedating, amnestic, and coordination-impairing effects. Even if lorazepam is not strongly CYP-metabolized, the interaction is pharmacodynamic and can still cause dangerous impairment. Combining them raises the risk of falls, blackouts, aspiration, and respiratory depression.
Mechanism. Lorazepam potentiates GABA-A receptor signaling. Alcohol adds GABAergic inhibition and reduces excitatory glutamatergic tone, causing additive CNS depression independent of hepatic metabolism.
Recommendation. Avoid alcohol while taking lorazepam. If alcohol was used, do not take extra lorazepam for anxiety or sleep without medical guidance. Seek urgent care for severe sedation, slow breathing, or inability to stay awake.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alcohol and Lorazepam are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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