NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Alcohol and Methotrexate: what the published research says

PubMed indexes 3 records that name Alcohol and Methotrexate together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Alcohol and Methotrexate. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

3 studies naming Alcohol and Methotrexate.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Methotrexate use and alcohol.

Clinical and experimental rheumatology · 2010 · PMID 21044443

ReviewHuman subjects

“A literature review was performed to look at the interactions between alcohol and methotrexate in non-malignant disease. The evidence from research into psoriasis and inflammatory arthritis, and an overview of international and national guidelines, was amalgamated into some consensus recommendations.”

Price et al. · From the abstract

Names both Alcohol and Methotrexate in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Alcohol, Methotrexate, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.