NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Alcohol and Morphine: what the published research says

PubMed indexes 5 records that name Alcohol and Morphine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Alcohol and Morphine. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

5 studies naming Alcohol and Morphine.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Alcohol inhibits morphine/cocaine reward memory acquisition and reconsolidation in rats.

Psychopharmacology · 2020 · PMID 31912191

Animal study

“The results suggested that pre-exposure alcohol dose-dependently attenuated morphine- or cocaine-induced place preference and prevented drug reinstatement in rats by disrupting memory reconsolidation, which may be explained by the inhibitory effect of alcohol on dopaminergic and glutamatergic neurotransmission.”

Zhu et al. · Authors' conclusion

Names both Alcohol and Morphine in its title.

Nicotine, alcohol and cocaine coupling to reward processes via endogenous morphine signaling: the dopamine-morphine hypothesis.

Medical science monitor : international medical journal of experimental and clinical research · 2007 · PMID 17534245

Research Support, N.I.H., ExtramuralReviewHuman subjects

“However, artificial stimulants can be detrimental, since flexibility and normal control of behavior are deteriorated. Additionally, addictive drugs are capable of directly acting on reward pathways, now, in part, via endogenous morphine processes.”

Stefano et al. · From the abstract

Names both Alcohol and Morphine in its title.

The stimulus properties of morphine and ethanol.

Psychopharmacologia · 1975 · PMID 1208757

Research Support, U.S. Gov't, Non-P.H.S.Animal study

“When a range of doses of levorphanol (0.1-3 mg/kg) and dextrorphan (3-100 mg/kg) was tested in morphine trained animals, only levorphanol was able to substitute for morphine. The present results suggest that the stimulus properties of morphine represent typical opiate effects.”

Winter · From the abstract

Names both Alcohol and Morphine in its title.

Oral hydromorphone extended-release.

The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists · 2010 · PMID 21172762

Comparative StudyReviewHuman subjects

“Hydromorphone ER is the newest oral opioid to enter a crowded marketplace now totaling 15 different Schedule 2 opioids (including tapentadol), and tramadol, available in oral, parenteral, rectal, transdermal, transmucosal, and intranasal formulations. It does not appear to have any unique assets or liabilities and should be considered as one of many oral opioids available for the management of persistent pain of moderate-to-severe intensity.”

Guay · Authors' conclusion

Names Alcohol and Morphine together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Alcohol, Morphine, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.