NutriStack
Alcohol and Tizanidine, a caution.
Alcohol can add to tizanidine's sedation, dizziness, low blood pressure, and fainting risk. A published case report describes syncope after concomitant tizanidine and alcohol use. This is especially concerning when standing up, driving, or combining with other blood-pressure-lowering or sedating substances.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Alcohol and Tizanidine
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Alcohol can add to tizanidine's sedation, dizziness, low blood pressure, and fainting risk. A published case report describes syncope after concomitant tizanidine and alcohol use. This is especially concerning when standing up, driving, or combining with other blood-pressure-lowering or sedating substances.
Mechanism. Tizanidine is an alpha-2 adrenergic agonist that can reduce sympathetic tone, causing sedation and hypotension. Alcohol adds central nervous system depression and vasodilatory effects, increasing the chance of oversedation, orthostatic symptoms, and syncope.
Recommendation. Avoid alcohol while taking tizanidine. If alcohol was used, do not drive and be careful standing or walking until the effects are clearly gone. Seek help for fainting, severe weakness, confusion, or trouble breathing.
Sources (2)
- Forsah SF, Ugwendum D, Arrey Agbor DB, Ndema N, Ndemazie NB, Kankeu Tonpouwo G, et al. Syncope Secondary to Concomitant Ingestion of Tizanidine and Alcohol in a Patient With Alcohol Use Disorder. Cureus. 2024;16(3):e57249. PMID 38686239
- Witenko C, Moorman-Li R, Motycka C, Duane K, Hincapie-Castillo J, Leonard P, et al. Considerations for the appropriate use of skeletal muscle relaxants for the management of acute low back pain. P T. 2014;39(6):427-435. PMID 25050056
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alcohol and Tizanidine are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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