What kind of interaction is it?

Conflict: combining the two is generally not recommended without clinician oversight.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Alcohol + Vitamin B1 pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × SupplementReviewed May 2026

Alcohol and Vitamin B1, a conflict.

Q: Can I take Alcohol and Vitamin B1 together?

Generally not recommended together. Alcohol and Vitamin B1 have a documented conflict. Chronic alcohol intake depletes thiamine (B1) and impairs its absorption and activation, raising the risk of Wernicke encephalopathy and Korsakoff syndrome.

Q: How does this affect a NutriStack Stack Score?

-10 to your Stack Score per scored conflict row.

Chronic alcohol intake depletes thiamine (B1) and impairs its absorption and activation, raising the risk of Wernicke encephalopathy and Korsakoff syndrome.

2 primary source citations. Strong evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Alcohol and Vitamin B1
Pair type: Conflict
Evidence (highest tier): Strong
Source citations: 2 sources
Stack Score effect: −10 to your Stack Score (per scored conflict row).
Scope: Supplement × Supplement
Last verified: May 30, 2026

Conflict · Strong evidence

Conflict

What is happening. Chronic alcohol intake depletes thiamine (B1) and impairs its absorption and activation, raising the risk of Wernicke encephalopathy and Korsakoff syndrome.

Mechanism. Alcohol reduces active transport of thiamine across the intestinal mucosa and inhibits hepatic conversion of thiamine to its active coenzyme thiamine pyrophosphate, while increasing urinary thiamine loss.

Recommendation. Do not treat alcohol use as safe. If alcohol is consumed regularly, arrange thiamine repletion under medical supervision, and seek medical advice for any neurological symptoms.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Alcohol and Vitamin B1 are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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